Metabolism Alprazolam is thoroughly metabolized in people, largely by cytochrome P450 3A4 (CYP3A4), to two major Lively metabolites while in the plasma: 4-hydroxyalprazolam and ?-hydroxyalprazolam. The plasma circulation levels of The 2 Lively metabolites are below four% from the guardian. The noted relative potencies in benzodiazepine receptor bin